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How does the disease bullous pemphigoid effect the epidermis?

Pemphigus and bullous pemphigoid are autoantibody-mediated blistering skin diseases. In pemphigus, keratinocytes in epidermis and mucous membranes lose cell-cell adhesion, and in pemphigoid, the basal keratinocytes lose adhesion to the basement membrane.

What are the signs and symptoms of bullous pemphigoid (BP)?

Signs and Symptoms of Bullous Pemphigoid. The signs and symptoms of Bullous Pemphigoid (BP) may include: Itching skin, weeks or months before blisters form; Large blisters that don’t easily rupture when touched, often along creases or folds in the skin; Skin around the blisters that is normal, reddish or darker than normal; Eczema or a hive ...

What is the prognosis of bullous pemphigoid (BP)?

What is the prognosis for bullous pemphigoid? Bullous pemphigoid usually goes away within 5 years, and generally responds well to treatment. However, blisters that rupture and become infected can lead to a life-threatening condition called sepsis. For this reason, it is important to seek treatment at your first sign of symptoms.

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