codeine metabolism | How codeine metabolism affects its clinical use

Keyword	CPC	PCC	Volume	Score	Length of keyword
codeine metabolism	1.91	0.4	9884	72	18
codeine	0.1	0.2	6320	47	7
metabolism	1.71	0.9	7289	6	10

Keyword	CPC	PCC	Volume	Score
codeine metabolism liver	1.39	0.2	4004	21
codeine metabolism variation	1.04	0.8	2293	26
codeine metabolism into morphine	1.38	0.8	5545	75
codeine metabolism cyp2d6	1.2	0.5	2504	31
codeine metabolism pediatrics	1.05	0.3	2349	1
codeine and dihydrocodeine metabolism	1.53	0.2	7153	49
can codeine be a metabolite of morphine	0.02	0.7	6521	49
codeine turns to morphine	1.87	0.3	1525	65
codeine breaks down into morphine	0.64	0.5	1723	68
what converts codeine to morphine	1.29	0.3	9334	69
does codeine become morphine	0.04	0.2	468	44
morphine related to codeine	0.04	0.1	4139	78
codeine vs morphine chemical structure	1.86	0.7	6041	58
how strong is codeine compared to morphine	1.39	0.8	5804	60
codeine equivalent in morphine	1.36	0.2	7018	47
what does codeine metabolize to	0.13	1	8494	26
how is codeine metabolized in the body	0.75	0.8	1718	36
is codeine made from morphine	0.42	1	4799	11
codeine morphine redox reaction	1.19	1	4988	12
structure of codeine morphine and diamorphine	1.69	0.4	5922	41
what is morphine metabolized into	1.34	0.3	6368	27
are codeine and morphine depressants	0.08	0.6	6275	3

Search Results related to codeine metabolism on Search Engine

How codeine metabolism affects its clinical use
pharmaceutical-journal.com

https://pharmaceutical-journal.com/article/ld/how-codeine-metabolism-affects-its-clinical-use

WebApr 27, 2021 · Metabolism. Codeine is primarily metabolised by two different pathways (see Figure) [2] . In most people, around 80% of codeine is conjugated to form codeine-6-glucuronide, which may have weak analgesic activity [2,7] . However, typically less than 10% of codeine undergoes CYP2D6-mediated O …

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Codeine - StatPearls - NCBI Bookshelf - National Center for
nih.gov

https://www.ncbi.nlm.nih.gov/books/NBK526029/

WebFeb 13, 2023 · Metabolism: Codeine is metabolized by conjugation to morphine (5% to 10%) and N-demethylation to norcodeine (~10%). Cytochrome P450 2D6 is the principal enzyme responsible for the transformation of codeine to morphine, and P450 3A4 is the major enzyme for converting codeine to norcodeine.

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Codeine and morphine metabolism | Pathway - PubChem
nih.gov

https://pubchem.ncbi.nlm.nih.gov/pathway/WikiPathways:WP1604

WebJan 29, 2019 · Between 0-15% of codeine is O-demethylated to morphine, the most active metabolite, which has a 200 fold greater affinity for the mu-opioid receptor compared to codeine. This metabolic reaction is performed by CYP2D6.

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Codeine Therapy and CYP2D6 Genotype - Medical Genetics …
nih.gov

https://www.ncbi.nlm.nih.gov/books/NBK100662/

WebSep 20, 2012 · The CYP2D6 enzyme converts codeine into its active metabolite, morphine, which provides its analgesic effect. Consequently, pain relief may be inadequate in individuals who have 2 inactive copies of CYP2D6 (“poor metabolizers”, PMs), because of reduced morphine levels.

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Pharmacokinetics of acetaminophen, codeine, and the codeine metabolites
nih.gov

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2867071/

WebCodeine is metabolized to numerous metabolites including morphine and codeine-6-glucuronide, which in addition to codeine appear to contribute to analgesic effects after codeine administration to humans ( Lötsch, et al, 2006 ).

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Pharmacokinetics of codeine and its metabolite morphine in
nature.com

https://www.nature.com/articles/6500406

WebJul 4, 2006 · Codeine is an analgesic drug acting on μ -opiate receptors predominantly via its metabolite morphine, which is formed almost exclusively by the genetically polymorphic enzyme cytochrome P450...

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Pharmacokinetics of codeine and its metabolite morphine in ... - PubMed
nih.gov

https://pubmed.ncbi.nlm.nih.gov/16819548/

WebPMID: 16819548. DOI: 10.1038/sj.tpj.6500406. Abstract. Codeine is an analgesic drug acting on mu-opiate receptors predominantly via its metabolite morphine, which is formed almost exclusively by the genetically polymorphic enzyme cytochrome P450 2D6 (CYP2D6).

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Codeine Metabolism Pathway | Pathway - PubChem
nih.gov

https://pubchem.ncbi.nlm.nih.gov/pathway/PathBank:SMP0000621

WebMay 30, 2019 · Description. Opiate receptors are coupled with G-protein receptors and function as both positive and negative regulators of synaptic transmission via G-proteins that activate effector proteins. Binding of the opiate stimulates the exchange of GTP for GDP on the G-protein complex.

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Codeine - an overview | ScienceDirect Topics
sciencedirect.com

https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/codeine

WebIntroduction. Codeine is a naturally occurring low-efficacy opium alkaloid. It is usually prepared for medicinal use by methylation of morphine to give a white crystalline powder or fine-needle-shaped white crystals. Odorless, bitter tasting, and affected by light, it is hydrated on exposure to air. Aqueous solutions are acidic and levorotatory.

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Opioid Metabolism - Mayo Clinic Proceedings
mayoclinicproceedings.org

https://www.mayoclinicproceedings.org/article/S0025-6196%2811%2960750-7/fulltext

WebOpioid Metabolism. Clinicians understand that individual patients differ in their response to specific opioid analgesics and that patients may require trials of several opioids before finding an agent that provides effective analgesia with acceptable tolerability.

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