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Keyword Analysis & Research: par1


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par11.0419475684

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Search Results related to par1 on Search Engine

  • Protease-activated receptor-1 (PAR-1): a promising molecular …

    nih.gov:443

    https://www.ncbi.nlm.nih.gov:443/pmc/articles/PMC5739818/

    WEBDec 5, 2017 · PAR-1 expression levels are higher in metastatic gastric cancer and have prognostic value [ 82 ]. PAR-1 is associated with prognostic factors for colorectal cancer [ 83 ]. PAR-1 could promote colorectal cancer growth, local invasion and metastasis [ 84 ].

    DA: 68 PA: 53 MOZ Rank: 57 Up or Down: Up

  • Protease-activated receptor - Wikipedia

    wikipedia.org:443

    https://en.wikipedia.org:443/wiki/Protease-activated_receptor

    WEBThere are four mammalian members of the protease-activated receptor (PAR) family: PAR1 – encoded by the gene F2R, PAR2 – F2RL1, PAR3 – F2RL2 and PAR4 – F2RL3, each of these genes has its locus on chromosome 5 except that of PAR4, which is on chromosome 19. The protease specificities, expression patterns, and functions of each PAR vary ...

    DA: 29 PA: 37 MOZ Rank: 97 Up or Down: Up

  • Protease-activated receptors (PARs): mechanisms of action and …

    nih.gov:443

    https://www.ncbi.nlm.nih.gov:443/pmc/articles/PMC6440139/

    WEBMar 29, 2019 · Activated PAR1 is internalized via clathrin- and dynamin-dependent mechanisms, and is sorted from early endosomes to lysosomes for degradation [196–199]. Although the mechanisms that terminate PAR1 signaling are not clearly understood, this process is known to involve phosphorylation, ubiquitination, and recruitment of β-arrestin …

    DA: 63 PA: 65 MOZ Rank: 69 Up or Down: Up

  • PAR1 signaling: The Big Picture - PMC - National Center for

    nih.gov:443

    https://www.ncbi.nlm.nih.gov:443/pmc/articles/PMC5714320/

    WEBPAR1 signaling coordinates several endothelial cell functions. Strategies to define the intricate signaling pathways downstream of PAR1 have evolved over the years. Initial efforts defined the specific G-proteins that couple to PAR1.

    DA: 45 PA: 78 MOZ Rank: 54 Up or Down: Up

  • Coagulation factor II receptor - Wikipedia

    wikipedia.org:443

    https://en.wikipedia.org:443/wiki/Coagulation_factor_II_receptor

    WEBProteinase-activated receptor 1 (PAR1) also known as protease-activated receptor 1 or coagulation factor II (thrombin) receptor is a protein that in humans is encoded by the F2R gene. PAR1 is a G protein-coupled receptor and one of four protease-activated receptors involved in the regulation of thrombotic response.

    DA: 6 PA: 82 MOZ Rank: 20 Up or Down: Up

  • Protease-activated receptor-1 (PAR-1): a promising molecular ... - PubMed

    nih.gov:443

    https://pubmed.ncbi.nlm.nih.gov:443/29291033/

    WEBSep 18, 2017 · PAR-1 is expressed not only in epithelium, neurons, astrocytes, immune cells, but also in cancer-associated fibroblasts, ECs (epithelial cells), myocytes of blood vessels, mast cells, and macrophages in tumor microenvironment, whereas PAR-1 stimulates macrophages to synthesize and secrete thrombin as well as other growth …

    DA: 84 PA: 85 MOZ Rank: 69 Up or Down: Up

  • High-resolution crystal structure of human protease-activated …

    nature.com:443

    https://www.nature.com:443/articles/nature11701

    WEBDec 9, 2012 · Nature - The X-ray crystal structure of the human protease-activated receptor 1 (PAR1) bound to vorapaxar, a PAR1 antagonist, has been determined at 2.2 Å resolution. PAR1, also known as...

    DA: 35 PA: 48 MOZ Rank: 1 Up or Down: Up

  • Targeting proteinase-activated receptors: therapeutic potential …

    nature.com:443

    https://www.nature.com:443/articles/nrd3615

    WEBJan 3, 2012 · Proteinase-activated receptors (PARs), a family of four seven-transmembrane G protein-coupled receptors, act as targets for signalling by various proteolytic enzymes. PARs are characterized...

    DA: 63 PA: 11 MOZ Rank: 76 Up or Down: Up

  • Proteinase Activated Receptor 1 - an overview - ScienceDirect

    sciencedirect.com:443

    https://www.sciencedirect.com:443/topics/medicine-and-dentistry/proteinase-activated-receptor-1

    WEBProtease-Activated Receptor 1 Inhibitors. PAR-1 is the cognate receptor for thrombin, the most potent activator of platelet aggregation. vorapaxar (via PO, T 1/2 8 days) is a reversible antagonist of PAR-1; however, due to its markedly long half-life, it is effectively an irreversible platelet function inhibitor.

    DA: 83 PA: 96 MOZ Rank: 59 Up or Down: Up

  • Protease-activated receptor 1 (PAR1) inhibits synaptic NMDARs ... - PubMed

    nih.gov:443

    https://pubmed.ncbi.nlm.nih.gov:443/32891865/

    WEBPAR1 activation inhibits synaptic NMDARs in SNpc DAergic neurons, without affecting AMPARs. PAR1-sensitive NMDARs contain GluN2B/GluN2D subunits. Moreover, PAR1-mediated NMDARs hypofunction is reliant on NMDARs internalization, as PAR1 stimulation increases NMDARs intracellular levels and pharmacological limitation of NMDARs …

    DA: 45 PA: 33 MOZ Rank: 59 Up or Down: Up