|Keyword||CPC||PCC||Volume||Score||Length of keyword|
|par16 vs par20||0.55||0.7||7312||89|
|par16 light bulb||0.13||1||7267||48|
|par 1 receptor||1.91||0.3||8342||70|
|par16 led bulb dimmable||0.99||0.3||1136||78|
|par16 halogen light bulbs||1.44||0.7||1947||76|
|par16 vs par20 led||0.05||1||5470||38|
Proteinase-activated receptor 1 (PAR1) also known as Protease-activated receptor 1 or coagulation factor II (thrombin) receptor is a protein that in humans is encoded by the F2R gene.What is the history of PAR-1?
INTRODUCTION PAR-1 was the first member of the PARs (protease-activated receptors) family, which was found simultaneously by both two independent laboratories in 1991, during the process of identifying GPCR (G protein-coupled receptors) that mediate thrombin signal pathway in both human and hamster cells [1–3].What is the role of PAR1 in coagulation?
PAR1 plays a major role in orchestrating the interplay between coagulation and inflammation [2-5]. PAR1 is the primary cell-surface receptor responsible for thrombin-mediated platelet aggregation in humans, but is also activated by many other proteases - including activated protein C (APC) and its receptor, the endothelial protein C receptor.What is protease-activated receptor 1 (PAR1)?
Marvin T. Nieman, in Platelets (Fourth Edition), 2019 Protease-activated receptor 1 (PAR1) was the first family member to be identified and was cloned in 1991. 3 PAR1 is widely expressed in a variety of tissues, but its expression on platelets is limited to primates and several other species (see section “ Expression of PARs Across Species ”).