Keyword Analysis & Research: par1

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What does PAR1 stand for?

Proteinase-activated receptor 1 (PAR1) also known as Protease-activated receptor 1 or coagulation factor II (thrombin) receptor is a protein that in humans is encoded by the F2R gene.

What is the history of PAR-1?

INTRODUCTION PAR-1 was the first member of the PARs (protease-activated receptors) family, which was found simultaneously by both two independent laboratories in 1991, during the process of identifying GPCR (G protein-coupled receptors) that mediate thrombin signal pathway in both human and hamster cells [1–3].

What is the role of PAR1 in coagulation?

PAR1 plays a major role in orchestrating the interplay between coagulation and inflammation [2-5]. PAR1 is the primary cell-surface receptor responsible for thrombin-mediated platelet aggregation in humans, but is also activated by many other proteases - including activated protein C (APC) and its receptor, the endothelial protein C receptor.

What is protease-activated receptor 1 (PAR1)?

Marvin T. Nieman, in Platelets (Fourth Edition), 2019 Protease-activated receptor 1 (PAR1) was the first family member to be identified and was cloned in 1991. 3 PAR1 is widely expressed in a variety of tissues, but its expression on platelets is limited to primates and several other species (see section “ Expression of PARs Across Species ”).

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