Keyword Analysis & Research: s100a4

wikipedia.org

https://en.wikipedia.org/wiki/Protein_S100-A4

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression … See more

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genecards.org

https://www.genecards.org/cgi-bin/carddisp.pl?gene=S100A4

OverviewTherapeutic targeting for cancerFunctionInteractionsFurther readingExternal linksS100A4, a member of the S100 calcium-binding protein family secreted by tumor and stromal cells, supports tumorigenesis by stimulating angiogenesis. Research demonstrated that S100A4 synergizes with vascular endothelial growth factor (VEGF), via the RAGE receptor, in promoting endothelial cell migration by increasing KDR expression and MMP-9 activity. In vivo overexpression of S100A4 led to a significant increase in tumor growth and vascularization in a human melanoma …

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nature.com

https://www.nature.com/articles/s41467-022-28372-y

WebFeb 9, 2022 · Furthermore, we identify S100A4 as a regulator of immune suppressive T and myeloid cells in GBM and demonstrate that deleting S100a4 in non-cancer cells is …

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nature.com

https://www.nature.com/articles/s41392-024-01797-1

Web3 days ago · It has been discovered that S100A4 is expressed by a subpopulation of macrophages in the fibrotic liver and extracellular S100A4 serves as a fibrotic factor …

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sciencedirect.com

https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/s100a4

WebS100A4 is a Wnt target gene that regulates cell migration, invasion, and angiogenesis in various cancers. It is also involved in the formation of brain metastases and the interaction …

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nih.gov

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7294136/

WebApr 19, 2020 · S100A4 protein, a ubiquitous member of the S100 family, has recently been discovered as a potential factor implicated in fibrotic diseases. S100A4 protein is released …

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nih.gov

https://www.ncbi.nlm.nih.gov/gene/6275

WebApr 7, 2024 · S100A4 modulates cell proliferation, apoptosis and fibrosis in the hyperplastic prostate. S100A4 reprofiles lipid metabolism in mast cells via RAGE and PPAR-gamma …

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genecards.org

https://www.genecards.org/cgi-bin/carddisp.pl?gene=S100A4

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