The S100 proteins are a family of low molecular-weight proteins found in vertebrates characterized by two calcium-binding sites that have helix-loop-helix ("EF-hand-type") conformation.At least 21 different S100 proteins are known. They are encoded by a family of genes whose symbols use the S100 prefix, for example, S100A1, S100A2, S100A3.They are …
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SOX10: a useful marker for identifying metastatic melanoma in ... - PubMed
In addition, there was a statistically significant increase in percentage of tumor cells stained by SOX10, compared with S100 protein, HMB-45, and Melan-A (P = 0.015, 0.000, and 0.001, respectively). SOX10 stained nodal nevi in a similar manner to S100 protein and Melan-A …
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6279 - Gene ResultS100A8 S100 calcium binding protein A8
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are …
S100 calcium-binding protein B (S100B) is a protein of the S-100 protein family.. S100 proteins are localized in the cytoplasm and nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21; however, …
Special stains may be used to differentiate spindle cell melanoma from other spindle cell tumours. The markers S100, SOX10, p75, HMB-45, laminin T, laminin NT, Melan-A, and c-KIT are positive after staining in spindle cell melanoma [2,3]. In spindle cell melanoma, a higher proportion of cells show Ki-67, cyclin D1, and survivin after staining [9].
S100 protein family has 25 known members solely in vertebrates coded by unique genes There are 22 proteins (S100A1-A8, trichohylin, filaggrin and repetin) ... Melanoma S100. Granular cell tumor. Granular cell tumor S100. Schwannoma. Schwannoma S100. Cases #6, #50, #54, #195, #218 and #252.
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Current state of melanoma diagnosis and treatment - PMC
Aug 01, 2019 · The most commonly used proliferation marker for melanoma is Ki-67, a protein involved in ribosomal transcription, the expression of which is associated with cell proliferation and is highly elevated in the most aggressive melanomas. 45, 57, 66, 67 In 1997 a second mitotic maker, phosphohistone H3 (PHH3), was introduced. 57, 68 PHH3 is a histone ...
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IHC Stain List » Pathology Laboratories - University of Florida
Sep 23, 2020 · The S100 protein was given its name because it is well soluble in 100% saturated ammonium sulfate under neutral conditions. 225 Up to date, at least 20 members of the S100 protein family have been ...
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Home Page: Journal of the American Academy of Dermatology
Jun 29, 2022 · The Journal of the American Academy of Dermatology (JAAD), the official scientific publication of the American Academy of Dermatology (AAD), aims to satisfy the educational needs of the dermatology community.As the specialty's leading journal, JAAD features original, peer-reviewed articles emphasizing: